Scientific publications
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Factor H–related proteins and their associated disorders
J Allergy Clin Immunol. 2025 Jun 9:S0091-6749(25)00619-0 https://doi: 10.1016/j.jaci.2025.05.024
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Encapsulants Affect Liposome Surface Interactions with Biological Systems
Clemens Spitzenberg, Christoph Bruckschlegel, Ferdinand Holzhausen, Sebastian Boesl-Bichlmeier, Coralie Pasquier, Patrick Nuernberger, Pierre Bauduin, and Antje J. Baeumner
Small 2025 Jun 19:e2505312.7. https://doi: 10.1002/smll.202505312
Development and characterization of novel ELISAs for the specific quantification of the factor H-related proteins 2 , 3 , 4 and 5
Rossum M.v., Veuskens B.R.J., Brouwer M.C., Mierlo G.v., Lucientes-Continente L., Goicoechea de Jorge E., Uzonyi B., Matola A.T., Józsi M., Müller G., Meter-Arkema A.M., Poppelaars F., Pauly D., Pouw R.B., Toonen E.J.M.
Journal of Innate Immunity 2025 Mar 26:1-24. https://doi: 10.1159/000545139
Common haplotypes within the chromosome 1q31.3 region determine systemic concentrations of the entire complement factor H protein family
Rossum M.v., Veuskens B.R.J., Brouwer M.C., Cattenstart E., Brouwer M.C., Mierlo G.v., Geissler J., Leeuwen K.v., Liu J., Anstadt R.A., Richards B.T., Hageman G.S., Kuijpers T.W., Toonen E.J.M., Pouw R.B.
Journal of Innate Immunity 2025 Mar 26:1-26. https://doi: 10.1159/000545342
Factor H-related 2 levels dictate FHR dimer composition
Veuskens B.R.J., Brouwer M.C., Mierlo G.v., Geissler J., van Leeuwen K., Derlagen M., Keijzer N.C.H., Hoogenboezem M., Kuijpers T.W., Pouw R.B..
Scientific Reports 2025 Mar 28;15(1):10669.https://doi: 10.1038/s41598-025-94064-4.
Decreased complement 4 and interleukin-10 as biomarkers in aqueous humour for non-exudative age-related macular degeneration: a case control study
Schikora J., Dort A., Wolf H. N., Józsi M., Pouw R. B., Bertelmann T., Bahlmann D., van Oterendorp C., Feltgen N., Hoerauf H., Pauly D., Klemming J.
Journal of Translational Medicine, Volume 23, Article number: 317 (2025) | https://doi.org/10.1186/s12967-024-05909-x
Autoantibodies Against Factor B and Factor H Without Pathogenic Effects in a Patient with Immune Complex-Mediated Membranoproliferative Glomerulonephritis
Matola A. T., Csuka D., Szilágyi Á., Rudnicki M., Prohászka Z., Józsi M., Uzonyi B.
Biomedicines, Volume 13, Issue 3, 2025, Article 648 | https://doi.org/10.3390/biomedicines13030648
Functional and structural characterization of mouse Factor H-related B protein unveils a novel dimerization domain shared by FHR-B and FH
Martín-Ambrosio Doménech A., González Sanz S., Márquez Tirado B., Juana-López L., Goicoechea de Jorge E., Rodríguez de Córdoba S., Martín Merinero H.
Front. Immunol., Volume 16, 29 January 2025, Sec. Molecular Innate Immunity | https://doi.org/10.3389/fimmu.2025.1522651
Prognostic significance of serum complement activation, neutrophil extracellular traps and extracellular DNA in newly diagnosed epithelial ovarian cancer
Ricciuti J., Liu Q., Khan A. N. M. N. H., Joseph J. M., Veuskens B., Giridharan T., Suzuki S., Emmons T., Yaffe M., Kuijpers T. W., Jongerius I., Brouwer M., Pouw R. B., Odunsi K., Frederick P., Mager K. L., Lele S., Gaulin N., Hakim C., Edwards R. P., Olawaiye A. B., Sukamanovich P., Taylor S., Elishaev E., Zsiros E., Modugno F., Moysich K., Segal B.
Gynecol Oncol., Volume 193, February 2025, Pages 49–57 | https://doi.org/10.1016/j.ygyno.2024.12.006
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The human factor H protein family – an update
Sándor Noémi, Schneider Andrea E., Matola Alexandra T., Barbai Veronika H., Bencze Dániel, Hammad Hani Hashim, Papp Alexandra, Kövesdi Dorottya, Uzonyi Barbara, Józsi Mihály
Front. Immunol., 12 February 2024 | https://doi.org/10.3389/fimmu.2024.1135490
Multiplexed electrochemical liposomes applied to the detection of nucleic acids for Influenza A, Influenza B and SARS-CoV-2
Florian Gerstl, Michael Loessl, Veronika Borggraefe, and Antje J. Baeumner
Anal Bioanal Chem. 2024; 416(15): 3487–3500. | https://doi.org/10.1007/s00216-024-05145-8
Complement alternative pathway determines disease susceptibility and severity in antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis
Laura Lucientes-Continente, Gema Fernández-Juárez, Bárbara Márquez-Tirado, Laura Jiménez-Villegas, Mercedes Acevedo, Teresa Cavero, Luís Sánchez Cámara, Juliana Draibe, Paula Anton-Pampols, Fernando Caravaca-Fontán, Manuel Praga, Javier Villacorta, Elena Goicoechea de Jorge
Kidney International 2023 | https://doi.org/10.1016/j.kint.2023.10.013
Editorial: Current challenges in complement diagnostics
Per H. Nilsson, Lillemoor Skattum, Erik JM Toonen
Front. Immunol., 24 November 2023 | https://doi.org/10.3389/fimmu.2023.1334050
Factor H-related protein 3 (FHR-3) deposition in kidney allografts – localization and correlation with complement activation
Felix Poppelaars, Nicole Schäfer, Anita H. Meter-Arkema, Shrey Purohit, Bernardo Faria, Mariana Gaya da Costa, V. Michael Holers, Mohamed R. Daha, Diana Pauly, Marc A. Seelen, Joshua M. Thurmannen
preprint medRxiv 2023.10.24.23297478 | https://doi.org/10.1101/2023.10.24.23297478
Editorial: Updates on the complement system in kidney diseases
Robert Bulla and Mihály Józsi
Front. Immunol., 06 April 2023 | https://doi.org/10.3389/fimmu.2023.1196487
The Factor H protein family: The switchers of the complement alternative pathway
Laura Lucientes-Continente, Bárbara Márquez-Tirado and Elena Goicoechea de Jorge
Immunol Rev 2023 Jan;313(1):25-45. | https://doi.org/10.1111/imr.13166
Evaluating the clinical utility of measuring levels of factor H and the related proteins
Pratiti Banerjee, Bert Veuskens, Elena Goicoechea de Jorge, Mihály Józsi, Antje J Baeumner, Mark-Steven Steiner, Richard B Pouw, Erik J M Toonen, Diana Pauly, Felix Poppelaars; SciFiMed Consortium
Mol. Immunol., 2022 Nov;151:166-182. I https://research.rug.nl/en/publications/evaluating-the-clinical-utility-of-measuring-levels-of-factor-h
Pitfalls in complement analysis: A systematic literature review of assessing complement activation
Ricardo J. M. G. E. Brandwijk, Marloes A. H. M. Michels, Mara van Rossum, Aline H. de Nooijer, Per H. Nilsson, Wieke C. C. de Bruin and Erik J. M. Toonen
Front. Immunol., 18 October 2022 I https://doi.org/10.3389/fimmu.2022.1007102
Factor H-Related Protein 1 Drives Disease Susceptibility and Prognosis in C3 Glomerulopathy
Bárbara Márquez-Tirado, Josué Gutiérrez-Tenorio, Agustín Tortajada, Laura Lucientes Continente, Fernando Caravaca-Fontán, Talat H. Malik, Raquel Roldán Montero, Sandra Elías, Ana Saiz Gonzalez, Gema Fernández-Juarez, Pilar Sánchez-Corral, Matthew C. Pickering, Manuel Praga, Santiago Rodríguez de Córdoba and Elena Goicoechea de Jorge
JASN May 2022 | https://doi.org/10.1681/ASN.2021101318
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Complement Factor H-Related Proteins FHR1 and FHR5 Interact With Extracellular Matrix Ligands, Reduce Factor H Regulatory Activity and Enhance Complement Activation
Alexandra Papp, Krisztián Papp, Barbara Uzonyi, Marcell Cserhalmi, Ádám I. Csincsi, Zsóka Szabó, Zsófia Bánlaki, David Ermert, Zoltán Prohászka, Anna Erdei, Viviana P. Ferreira, Anna M. Blom, Mihály Józsi
Front. Immunol., 22 March 2022 | https://doi.org/10.3389/fimmu.2022.845953
Editorial: Function and Dysfunction of Complement Factor H
Mihály Józsi, Pauli Nigel Barlow and Seppo Meri
Front. Immunol., 13 January 2022 | https://doi.org/10.3389/fimmu.2021.831044
Complement Factor H-Related 3 Enhanced Inflammation and Complement Activation in Human RPE Cells
Nicole Schäfer, Anas Rasras, Delia M. Ormenisan, Sabine Amslinger, Volker Enzmann, Herbert Jägle and Diana Pauly
Front. Immunol., 08 November 2021 | https://doi.org/10.3389/fimmu.2021.769242
The Contribution of Complement to the Pathogenesis of IgA Nephropathy: Are Complement-Targeted Therapies Moving from Rare Disorders to More Common Diseases?
Felix Poppelaars, Bernardo Faria, Wilhelm Schwaeble and Mohamed R. Daha
J. Clin. Med. 2021,10, 4715. 14 October 2021 I https://doi.org/10.3390/jcm10204715
Complement Factor H Family Proteins Modulate Monocyte and Neutrophil Granulocyte Functions
Éva Kárpáti, Mariann Kremlitzka, Noémi Sándor, Dávid Hajnal, Andrea E. Schneider and Mihály Józsi
Front. Immunol., 04 October 2021 | https://doi.org/10.3389/fimmu.2021.660852
A Family Affair: Addressing the Challenges of Factor H and the Related Proteins
Felix Poppelaars, Elena Goicoechea de Jorge, Ilse Jongerius, Antje J. Baeumner, Mark-Steven Steiner, Mihály Józsi, Erik J. M. Toonen, Diana Pauly and the SciFiMed consortium
Front. Immunol., 30 March 2021 | https://doi.org/10.3389/fimmu.2021.660194