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Complement Factor H-Related 3 Enhanced Inflammation and Complement Activation in Human RPE Cells


🔬✨ Exciting new findings on complement Factor H-Related 3 (FHR-3) by Nicole Schäfer, Diana Pauly, and their team! FHR-3 is a key regulator of the complement system and is linked to diseases like age-related macular degeneration (AMD).


🔍The team's research focused on uncovering the non-canonical, local cellular functions of FHR-3. They found that FHR-3 binds to oxidative stress epitopes and competes with FH for interaction. Interestingly, FHR-3 was internalized by retinal pigment epithelium (RPE) cells, and it modulated the expression of complement components (C3, FB) and receptors (C3aR, CR3) in these cells.


💡 Their findings revealed that FHR-3 triggered a pro-inflammatory microenvironment in RPE cells, activating the inflammasome NLRP3 and inducing the secretion of pro-inflammatory cytokines such as IL-1ß, IL-18, IL-6, and TNF-α.


🎯 The team's previously published monoclonal anti-FHR-3 antibody, RETC-2-ximab, showed potential in ameliorating the effects of FHR-3 on ARPE-19 cells. These discoveries suggest FHR-3 could be a promising target for therapeutic approaches in treating degenerative diseases like AMD.


👏 Kudos to Nicole Schäfer, Diana Pauly, and their team for their groundbreaking research! Stay tuned for more updates in this field! #complementfactorH #AMD #inflammation #research #RPEcells


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