Harmless Autoantibodies? A New Perspective in Kidney Disease 🧩🛡️🔍

Join Alexandra Matola, Mihály Józsi, Barbara Uzonyi, and their ELTE team from the SciFiMed Consortium as they explore a fascinating case of kidney disease (MPGN) involving unusual autoantibodies against complement proteins Factor B (FB) and Factor H (FH).

🔬 What's Remarkable?

• The patient had autoantibodies targeting Factor B and Factor H, key proteins of the immune complement system.

• Detailed analyses revealed exactly where these antibodies bind and how they behave—yet surprisingly, they did not cause harm or significant dysfunction to the complement system in laboratory tests.

  
  

🌀 Key Findings:

• Although autoantibodies formed complexes with FB and FH in the patient’s blood, they showed minimal or no harmful effects on immune system functions tested.

• The study suggests that autoantibodies found in certain kidney diseases (MPGN) may sometimes be harmless, challenging assumptions about their pathogenic role.

  
  

🚀 ELTE SciFiMed Highlight:

This discovery by the ELTE SciFiMed team brings fresh insights into how autoantibodies interact with immune proteins and underlines the complexity of autoimmunity in kidney diseases.

🔑 Why Is This Important?

Understanding when autoantibodies are truly harmful helps refine diagnostics, treatment decisions, and patient care in autoimmune kidney diseases.

#ELTE #SciFiMed #KidneyResearch #Autoimmunity #ComplementSystem #MPGN #ImmuneComplexes #BiomedicalInnovation

https://doi.org/10.3390/biomedicines13030648