Mouse FHR-B Reveals a Novel Way Proteins Team Up to Regulate Immunity! 🐭🛡️🧩

Join Elena Goicoechea de Jorge (SciFiMed team) and her colleagues as they explore Factor H-related protein B (FHR-B) in mice. Their research reveals how FHR-B forms unique molecular pairs (dimers), crucially influencing immune regulation.

🧬 What's New and Exciting?

• Mouse FHR-B binds strongly to complement proteins (C3, C3b, iC3b, C3dg) and competes with Factor H, influencing immune responses.

• The study identified a completely new dimerization domain (protein pairing region) shared between mouse FHR-B and mouse Factor H, highlighting evolutionary connections to human proteins.

  
  

🔍 Why Does This Matter?

Understanding how mouse FHR proteins function and pair up helps researchers clarify similarities and differences between mouse and human immune regulation, crucial for accurately modeling human diseases.

🚀 Quick Takeaway:

This research uncovers new structural insights into mouse immune proteins, helping bridge knowledge gaps between mice and humans—important for developing future therapies.

#MouseImmunology #ComplementSystem #SciFiMed #ProteinStructure #ImmuneResearch #TranslationalScience

DOI 10.3389/fimmu.2025.1522651