Prognostic significance of serum complement activation, neutrophil extracellular traps and extracellular DNA in newly diagnosed epithelial ovarian cancer
- dianapauly
- Jul 4
- 1 min read
Highlights
• Immune checkpoint inhibitors have been shown to be largely ineffective as a treatment for epithelial ovarian cancer (EOC).
• Neutrophils, NETs, and complement signaling have previously been implicated in inducing T cell suppression.
• In this study, complement activation, NETs, extracellular gDNA (cellular damage marker), were associated with worse EOC survival.
• Ascites fluid factor H, a negative regulator of complement activation, was associated with improved survival
12 months Embargo - ask for a PDF directly at the authors contact :)
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