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Prognostic significance of serum complement activation, neutrophil extracellular traps and extracellular DNA in newly diagnosed epithelial ovarian cancer

Highlights

• Immune checkpoint inhibitors have been shown to be largely ineffective as a treatment for epithelial ovarian cancer (EOC).

• Neutrophils, NETs, and complement signaling have previously been implicated in inducing T cell suppression.

• In this study, complement activation, NETs, extracellular gDNA (cellular damage marker), were associated with worse EOC survival.

• Ascites fluid factor H, a negative regulator of complement activation, was associated with improved survival


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This project has received funding from the European Union’s Horizon 2020

research and innovation programme under grant agreement No 899163

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