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Complement Factor H Family Proteins Modulate Monocyte and Neutrophil Granulocyte Functions

Exploring the Impact of Factor H Family Proteins on Monocyte and Neutrophil Functions 🧬👥


Embark on a journey into the intricate functions of the complement system to unravel the diverse roles of Factor H (FH) family proteins in influencing monocytes and neutrophils. 🌐📊


👉 Unveiling Functional Insights: Factor H (FH), a critical regulator of the alternative pathway of complement activation, goes beyond its traditional role, binding to immune cells and modulating their functions. In this study, FH and its variants—FH-like protein 1 (FHL-1), FH-related (FHR) proteins (FHR-1 and FHR-5), and the engineered complement inhibitor mini-FH—were investigated for their impact on two key innate immune cell types: monocytes and neutrophilic granulocytes.


1️⃣ Binding Capabilities: Similar to FH, other Factor H family proteins, including FHL-1, FHR-1, and FHR-5, as well as the engineered mini-FH, demonstrated the ability to bind to both monocytes and neutrophils. This sets the stage for exploring their functional outcomes.


2️⃣ Functional Insights: FH and FHR-1, when immobilized, exhibited inhibition of PMA-induced NET formation while enhancing neutrophil adherence and IL-8 production. FHL-1 uniquely increased cell adherence, and FHR-5 showed no significant alteration in these functions. Monocyte adherence was boosted on surfaces coated with FH, recombinant mini-FH, and FHL-1. These molecules also heightened the secretion of inflammatory cytokines IL-1β and TNFα, with FHL-1 and mini-FH further enhancing IL-10 release.


3️⃣ Beyond Complement Inhibition: The study underscores that FH-based complement inhibitors, particularly mini-FH, may extend their influence beyond the classical role of complement activation inhibition. This opens new avenues for understanding the non-canonical functions of FH family proteins.


👩‍🔬 Research Implications: These findings reveal diverse effects of FH and its family members on monocytes and neutrophils, impacting crucial aspects of pathogen elimination. The study not only enhances our understanding of their roles in infection protection but also suggests potential applications in vaccine development.

🔍 Dive into the complexities of innate immunity with this enlightening research, shedding light on the multifaceted functions of Factor H family proteins! #InnateImmunity #ComplementSystem #ResearchInsights 🌐🔬

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