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Editorial: Updates on the complement system in kidney diseases

📰 Exploring the Latest in Kidney Diseases and the Intricate Role of the Complement System 🧬👥


Join the journey through the realm of kidney diseases with Roberta Bulla and Mihály Józsi as they unveil the latest updates on the complement system's involvement in these conditions. 🌐📊


👉 The Complement System Unveiled:


The complement system, an ancient arm of the immune system, plays diverse roles, from protecting against pathogens to removing waste material. Delving into 13 insightful papers, this Research Topic covers various aspects of the complement system's role in kidney diseases.


1️⃣ Atypical Hemolytic Uremic Syndrome (aHUS):


Explore novel insights into aHUS, a thrombotic microangiopathy with complement abnormalities as predisposing factors. Uncover the impact of mutations in complement components like C3 and factor B (FB) and the key enzyme factor I in aHUS pathogenesis.


2️⃣ Complement in Acute Kidney Injury (AKI) to Chronic Kidney Disease (CKD) Transition:


Understand the link between complement activation and the progression from AKI to CKD. Review recent findings on how complement inhibitors might be utilized to prevent AKI and CKD progression, ultimately improving graft function.


3️⃣ Renal Damage and Infections:


Explore the renal implications of COVID-19, with analyses of kidney biopsies revealing complement factors' involvement. Discover the association between COVID-19 vaccination and aHUS, emphasizing the need for awareness in patients with vaccine-induced thrombocytopenia.


4️⃣ Extracellular Matrix (ECM) and Complement Activation:


Uncover the interaction between FH-Related Proteins FHR-1 and FHR-5 with ECM elements, influencing complement regulation. Gain insights into the balance of FH and FHR-1/FHR-5 in the glomerular glycocalyx and its impact on C3 glomerulopathy (C3G) pathogenesis.


5️⃣ New Experimental Models for Diagnosis and Treatment:


Explore innovative in vitro models for studying complement activation on glycomatrix surfaces, providing a replicable method for evaluating complement system activity in C3G. Witness the potential of genetic manipulation (CD55 overexpression) in improving transplant outcomes.


👩‍⚕️ Conclusions:


This comprehensive Research Topic sheds light on functional characterization, activation and regulation mechanisms, infectious associations, and experimental models, offering valuable insights into the complement system's role in kidney diseases.


📚 Dive deep into the intricate world of kidney diseases and complement system dynamics with this enlightening collection!


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