Richard B. Pouw is Research Fellow and group leader at the Department of Immunopathology of Sanquin Research, the Dutch Blood Supply Foundation, in Amsterdam, the Netherlands. His research group focuses on complement regulation and dysregulation on human surfaces in relation to immunological diseases and with special interest in FH and its related proteins.
In 2012 he graduated in Biomedical Sciences at the University of Amsterdam, the Netherlands. Richard performed his PhD studies on FH and FHR proteins at Sanquin Research and obtained his PhD Cum laude from the Faculty of Medicine of the University of Amsterdam in 2018. He joined the Molecular Pharmacy lab of Daniel Ricklin at the University of Basel for 4 years before returning to Sanquin Research in 2022 where he continues to work on the complement system in immunopathology
1. Pouw RB, Brouwer MC, de Gast M, van Beek AE, van den Heuvel LP, Schmidt CQ, van der Ende A, Sánchez-Corral P, Kuijpers TW, Wouters D. Potentiation of complement regulator factor H protects human endothelial cells from complement attack in aHUS sera. Blood Adv. 3: 621–632, (2019).
2. Pouw RB, Gómez Delgado I, López Lera A, Rodríguez de Córdoba S, Wouters D, Kuijpers TW, Sánchez-Corral P. High complement factor H-related (FHR)-3 levels are associated with the atypical hemolytic-uremic syndrome-risk allele CFHR3*B. Front. Immunol. 9: 848, (2018).
3. Pouw RB, Brouwer MC, Beek AE Van, Józsi M, Wouters D, Kuijpers TW. Complement factor H-related protein 4A is the dominant circulating splice variant of CFHR4. Front. Immunol. 9: 729, (2018).
4. Van Beek AE, Pouw RB, Brouwer MC, van Mierlo G, Geissler J, Ooijevaar-de Heer P, de Boer M, van Leeuwen K, Rispens T, Wouters D, Kuijpers TW. FHR-1 and FHR-2 form homo- and heterodimers, while FHR-5 circulates only as homodimer in human plasma. Front. Immunol. 8: 1328, (2017). https://doi.org/10.3389/fimmu.2017.01328
5. Pouw RB, Brouwer MC, Geissler J, van Herpen L V, Zeerleder SS, Wuillemin WA, Wouters D, Kuijpers TW. Complement factor H-related protein 3 serum levels are low compared to factor H and mainly determined by gene copy number variation in CFHR3. PLoS One 11: e0152164, (2016). https://doi.org/10.1371/journal.pone.0152164