Mihály Józsi is professor and head of the Department of Immunology. His research focuses on the complement system, particularly the function and regulation of the alternative complement pathway, the structure and function of factor H and factor H-related proteins. He has identified novel ligands and functions of the factor H family proteins and characterized various disease-associated mutants and anti-factor H autoantibodies.
He graduated in Biology and obtained his PhD in 2002 from Eötvös Loránd University, Budapest, Hungary. Dr. Józsi was a research fellow, later a junior research group leader at Leibniz Institute for Natural Product Research and infection Biology (Jena, Germany). Between 2012 and 2017 he was leading a research group supported by the Hungarian Academy of Sciences. Since 2017 he is a staff member at the Department of Immunology (Eötvös Loránd University, Budapest, Hungary). Prof. Józsi combines teaching in immunology and research methodology with basic research in the field of innate immunity.
1. Kárpáti É, Papp A, Schneider AE, Hajnal D, Cserhalmi M, Csincsi ÁI, Uzonyi B, Józsi M. Interaction of the Factor H Family Proteins FHR-1 and FHR-5 With DNA and Dead Cells: Implications for the Regulation of Complement Activation and Opsonization. Front Immunol. 2020 Jul 16;11:1297. doi: 10.3389/fimmu.2020.01297. eCollection 2020.
2. Csincsi ÁI, Szabó Z, Bánlaki Z, Uzonyi B, Cserhalmi M, Kárpáti É, Tortajada A, Caesar JJE, Prohászka Z, Jokiranta TS, Lea SM, Rodríguez de Córdoba S, Józsi M. FHR-1 Binds to C-Reactive Protein and Enhances Rather than Inhibits Complement Activation. J Immunol. 2017 Jul 1;199(1):292-303. doi:10.4049/jimmunol.1600483.
3. Schneider AE, Sándor N, Kárpáti É, Józsi M. Complement factor H modulates the activation of human neutrophil granulocytes and the generation of neutrophil extracellular traps. Mol Immunol. 2016 Apr;72:37-48. doi: 10.1016/j.molimm.2016.02.011.
4. Csincsi ÁI, Kopp A, Zöldi M, Bánlaki Z, Uzonyi B, Hebecker M, Caesar JJ, Pickering MC, Daigo K, Hamakubo T, Lea SM, Goicoechea de Jorge E, Józsi M. Factor H-related protein 5 interacts with pentraxin 3 and the extracellular matrix and modulates complement activation. J Immunol. 2015 May 15;194(10):4963-73. doi:10.4049/jimmunol.1403121.
5. Hebecker M, Józsi M. Factor H-related protein 4 activates complement by serving as a platform for the assembly of alternative pathway C3 convertase via its interaction with C3b protein. J Biol Chem. 2012 Jun 1;287(23):19528-36. doi: 10.1074/jbc.M112.364471.