Work package 2 leader
Hycult biotechnology bv
5405 PB Uden
Research Gate profile
Erik Toonen works as a senior scientist / projectleader at the R&D department of Hycult Biotech. He has obtained experience in molecular and cell biological approaches to identify biomarkers for disease severity, treatment response and adverse reactions in immune- and inflammatory-associated diseases. He has extensive knowledge in the fields of (auto)immunity and inflammation and has expertise in all aspects of assay development.
He graduated in Life Sciences, at the Maastricht University, the Netherlands. Erik Toonen obtained his PhD in Medical Sciences and Genetics from the Radboud University medical center, Nijmegen, Netherlands. Dr. Toonen was appointed as a research scientist at MSD (Oss, Netherlands) and Radboud University medical center (Nijmegen, Netherlands). Since 2015 he is a senior scientist at the Department of R&D at Hycult Biotech (Uden, Netherlands).
1. Bongoni AK, Lu B, McRae JL, Salvaris EJ, Toonen EJM, Vikstrom I, Baz Morelli A, Pearse MJ, Cowan PJ. Complement-mediated Damage to the Glycocalyx Plays a Role in Renal Ischemia-reperfusion Injury in Mice. Transplant Direct. 2019 Mar 25;5(4):e341. doi: 10.1097/TXD.0000000000000881.
2. Loonen AJM, Leijtens S, Serin O, Hilbink M, Wever PC, van den Brule AJC, Toonen EJM. Soluble mannose receptor levels in blood correlate to disease severity in patients with community-acquired pneumonia. Immunol Lett. 2019 Feb;206:28-32. doi: 10.1016/j.imlet.2018.12.001.
3. Mirea AM, Tack CJ, Chavakis T, Joosten LAB, Toonen EJM. IL-1 Family Cytokine Pathways Underlying NAFLD: Towards New Treatment Strategies. Trends Mol Med. 2018 May;24(5):458-471. doi: 10.1016/j.molmed.2018.03.005.
4. Ellero-Simatos S, Fleuren WW, Bauerschmidt S, Dokter WH, Toonen EJ. Identification of gene signatures for prednisolone-induced metabolic dysfunction in collagen-induced arthritic mice. Pharmacogenomics. 2014 Apr;15(5):629-41. doi: 10.2217/pgs.14.3.
5. Development of anserological assay for standardized detection of Enterohemorrhagic Escherichia coli (EHEC) O157:H7 infections