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Elena Goicoechea de Jorge

Work package 7 leader

egoicoec[at]ucm.es

 

Universidad Complutense de Madrid

Department of Immunology, Ophthalmology and ORL

Avenida de Seneca 2

28040 Madrid

Spain

+34 665534625

Research Gate profile

Elena Goicoechea de Jorge is Ramón y Cajal researcher at the Department of Immunology at the University Complutense of Madrid, Spain. The main research line in her laboratory focuses the understanding of the biological role of the factor H protein family and how these proteins are involved in the pathogenesis of renal diseases.

Short CV

She graduated in Biochemistry, at the Universidad Autónoma de Madrid, Spain. Elena Goicoechea de Jorge obtained her PhD in Technical Biochemistry from the Universidad Autónoma de Madrid, Spain. Dr. de Jorge was appointed as a research scientist assistant at Imperial College (London, UK). In 2015 she settled as an independent researcher in the Department of Immunology at the Faculty of Medicine (University Complutense of Madrid, Madrid, Spain), where she combines her research activity with teaching.

Relevant publications

1. Goicoechea de Jorge E, Tortajada A, García SP, Gastoldi S, Merinero HM, García-Fernández J, Arjona E, Cao M, Remuzzi G, Noris M, Rodríguez de Córdoba S. Factor H Competitor Generated by Gene Conversion Events Associates with Atypical Hemolytic Uremic Syndrome. J Am Soc Nephrol. 2018 Jan;29(1):240-249. doi: 10.1681/ASN.2017050518.

 

2. Goicoechea de Jorge E, López Lera A, Bayarri-Olmos R, Yebenes H, Lopez-Trascasa M, Rodríguez de Córdoba S. Common and rare genetic variants of complement components in human disease. Mol Immunol. 2018 Oct;102:42-57. doi: 10.1016/j.molimm.2018.06.011.

 

3. Tortajada A, Gutiérrez E, Goicoechea de Jorge E, Anter J, Segarra A, Espinosa M, Blasco M, Roman E, Marco H, Quintana LF, Gutiérrez J, Pinto S, Lopez-Trascasa M, Praga M, Rodriguez de Córdoba S. Elevated factor H-related protein 1 and factor H pathogenic variants decrease complement regulation in IgA nephropathy. Kidney Int. 2017 Oct;92(4):953-963. doi: 10.1016/j.kint.2017.03.041.

 

4. Goicoechea de Jorge E, Caesar JJ, Malik TH, Patel M, Colledge M, Johnson S, Hakobyan S, Morgan BP, Harris CL, Pickering MC, Lea SM. Dimerization of complement factor H-related proteins modulates complement activation in vivo. Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4685-90. doi:10.1073/pnas.1219260110.

 

5. Gale DP, de Jorge EG, Cook HT, Martinez-Barricarte R, Hadjisavvas A, McLean AG, Pusey CD, Pierides A, Kyriacou K, Athanasiou Y, Voskarides K, Deltas C, Palmer A, Frémeaux-Bacchi V, de Cordoba SR, Maxwell PH, Pickering MC. Identification of a mutation in complement factor H-related protein 5 in patients of Cypriot origin with glomerulonephritis. Lancet. 2010 Sep 4;376(9743):794-801. doi: 10.1016/S0140-6736(10)60670-8.

This project has received funding from the European Union’s Horizon 2020

research and innovation programme under grant agreement No 899163

©2020 by SciFiMed.

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